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GNE-617 (hydrochloride)

GNE-617 (hydrochloride)

Item no.	HY-15766A-10mM
Manufacturer	MedChem Express
CASRN	2070014-99-0
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 2 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.28
Formula	C21H16ClF2N3O3S
Citations	[1]Zabka TS, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144(1):163-72.<br>[2]Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.
Smiles	O=C(NCC1=CC=C(S(C2=CC(F)=CC(F)=C2)(=O)=O)C=C1)C3=CN4C(C=C3)=NC=C4.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GNE617 hydrochloride, GNE 617 hydrochloride
Available
Product Description	GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	463.88
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	NAMPT
Pathway	Metabolic Enzyme/Protease

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HY-15766A-10mM-safety-datasheet.pdf