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(Z)-Leukadherin-1

(Z)-Leukadherin-1

Item no.	HY-15701A-10mg
Manufacturer	MedChem Express
CASRN	2055362-72-4
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C22H15NO4S2
Citations	[1]Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11(499).
Smiles	O=C(O)C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ADH-503 (free base)
Similar products	ADH-503 (free base)
Available
Product Description	(Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric CD11b agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	421.49
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)\|Methanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Complement System
Manufacturers Target	Complement System
Manufacturers Pathway	Immunology/Inflammation
Manufacturers Product type	Reference compound

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HY-15701A-10mg-safety-datasheet.pdf