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Ceritinib

Ceritinib

Item no.	HY-15656-100mg
Manufacturer	MedChem Express
CASRN	1032900-25-6
Amount	100 mg
Quantity options	100 mg 10g 10mM/1mL 10 mg 1 g 200 mg 2 g 500 mg 50 mg 5 g 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Lymphatic System Cancer Calcium Binding Protein Markers
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.98
Formula	C28H36ClN5O3S
Citations	AMB Express. 2022 Nov 28;12(1):150.<br>Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118712.<br>Cancer Chemother Pharmacol. 2018 Aug;82(2):251-263.<br>Cell Chem Biol. 2018 Aug 16;25(8):996-1005.e4.<br>Cell Discov. 2021 May 11;7(1):33.<br>Cell Physiol Biochem. 2018;45(4):1707-1716.<br>Cell Rep Med. 2023 Jan 10;100911.<br>Cell Signal. 2022 Jan 24;92:110264.<br>Eur J Drug Metab Pharmacokinet. 2021 Jul 18;1-11.<br>Eur J Med Chem. 2022: 114946.<br>Fundam Clin Pharmacol. 2021 Feb 1.<br>Harvard Medical School LINCS LIBRARY<br>J Pharm Pharmacol. 2020 Oct;72(10):1370-1382.<br>J Transl Med. 2021 Feb 27;19(1):91.<br>Mol Oncol. 2017 Aug;11(8):996-1006.<br>Mol Syst Biol. 2023 Dec 18.<br>Nat Cancer. 2022 Oct;3(10):1211-1227.<br>Nat Commun. 2024 Apr 23;15(1):3422.<br>Patent. US20200276189A1.<br>Patent. US20230158019A1.<br>RSC Adv. 2023 Mar 10;13(12):7929-7938.<br>Sci Signal. 2015 Dec 8;8(406):ra125. <br>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br>Science. 2017 Dec 1;358(6367):eaan4368.<br>Toxicol Appl Pharmacol. 2019 Nov 15;383:114781.<br>Universitat Autònoma de Barcelona. Biologia Molecular i Biomedicina. 2022 Aug.<br>Uppsala University. Department of Pharmaceutical Biosciences. 2022 Feb.<br>Xenobiotica. 2018 Oct;48(10):1059-1071. <br>bioRxiv. 2023 Jul 19.<br>[1]Rothschild SI. Ceritinib-a second-generation ALK inhibitor overcoming resistance in ALK-rearranged non-small celllung cancer. Transl Lung Cancer Res. 2014 Dec;3(6):379-81.<br>[2]Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90.<br>[3]Chen J, et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J Med Chem. 2013 Jul 25;56(14):5673-4.<br>[4]Tucker ER, et al. Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma. Mol Oncol. 2017 Aug;11(8):996-1006.
Smiles	CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LDK378
Available
Product Description	Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib (LDK378) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib (LDK378) shows great antitumor potency[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	558.14
Clinical_Information	Launched
Manufacturers Research Area	Cancer; Endocrinology
Solubility	DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Anaplastic lymphoma kinase (ALK); IGF-1R; Insulin Receptor
Pathway	Protein Tyrosine Kinase/RTK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-15656-100mg-safety-datasheet.pdf