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Filorexant

Filorexant

Item no.	HY-15653-10mg
Manufacturer	MedChem Express
CASRN	1088991-73-4
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.27
Formula	C24H25FN4O2
Citations	[1]Winrow CJ, et al. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62(2):978-87.<br/>[2]Coleman PJ, et al. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7(3):415-24, 337.
Smiles	CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-6096
Available
Product Description	Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	420.48
Clinical Information	Phase 2
Manufacturers Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Orexin Receptor (OX Receptor)
Manufacturers Target	Orexin Receptor (OX Receptor)
Isoform	OX2 Receptor
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-15653-10mg-safety-datasheet.pdf