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Salinomycin

Salinomycin

Item no.	HY-15597-5mg
Manufacturer	MedChem Express
CASRN	53003-10-4
Amount	5 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Food Safety Antibiotics Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Breast Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.39
Formula	C42H70O11
Citations	ACS Infect Dis. 2021 Aug 13;7(8):2390-2401.<br/>Acta Biomater. 2022 Aug 23;S1742-7061(22)00501-3.<br/>Anal Chem. 2022 Sep 19.<br/>Biomed J. 2020 Aug;43(4):368-374.<br/>bioRxiv. 2020 Jun.<br/>bioRxiv. 2023 Jan 17.<br/>bioRxiv. 2023 Jun 25.<br/>Biosens Bioelectron. 2024 Jul 1:255:116245.<br/>Cancers. 2020 Aug 5;12(8):2176.<br/>Cell Biosci. 2021 Aug 4;11(1):156.<br/>Cell Commun Signal. 2018 Nov 23;16(1):89.<br/>Cell Death Dis. 2023 Mar 11;14(3):193.<br/>EMBO Mol Med. 2019 Oct;11(10):e9930.<br/>Int J Mol Med. 2019 Oct;44(4):1289-1298.<br/>Int J Mol Sci. 2019 Jun 12;20(12):2861.<br/>Int J Mol Sci. 2023 Mar 21;24(6):5939.<br/>Int J Nanomedicine. 2020 Sep 15;15:6839-6854.<br/>J Bioenerg Biomembr. 2021 Aug 8.<br/>J Control Release. 2020 Oct 10;326:387-395.<br/>Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct.<br/>Oncol Rep. 2018 Aug;40(2):877-886.<br/>Pharmacol Res. 2020 May;155:104751.<br/>RSC Adv. 2021 Nov 2;11(56):35331-35341.<br/>Viruses. 2022, 14(8), 1734.<br/>Exp Ther Med. 2020 Mar;19(3):1835-1843.<br/>Int J Pharm. 2023 Feb 24;122779.<br/>[1]Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.<br/>[2]Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.<br/>[3]Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638.<br/>[4]Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8(7):578-82.<br/>[5]Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14(2):e0211916.<br/>[6]Naujokat C, et al. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658.
Smiles	[H][C@]1([C@](C)(CC2)O[C@]32[C@H](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@H]4C)O3)CC[C@@](CC)(O)[C@H](C)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Procoxacin
Available
Product Description	Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	751.00
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 36.7 mg/mL
Target	Antibiotic; Apoptosis; Autophagy; Bacterial; Mitophagy; Parasite; Wnt; β-catenin
Manufacturers Target	Antibiotic; Apoptosis; Autophagy; Bacterial; Mitophagy; Parasite; Wnt; β-catenin
Isoform	Coccidia
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-15597-5mg-safety-datasheet.pdf