L189

Item no.	HY-15588-50mg
Manufacturer	MedChem Express
CASRN	64232-83-3
Amount	50 mg
Quantity options	10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C11H10N4OS
Citations	[1]Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008<br/>[2]Devashree Jahagirdar, et al. Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa. Current Cancer Therapy Reviews, 2018, 14, 1-11.
Smiles	OC1=NC(S)=NC(N)=C1/N=C/C2=CC=CC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	64232-83-3
Available
Product Description	L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	246.29
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 33 mg/mL
Target	DNA/RNA Synthesis
Manufacturers Target	DNA/RNA Synthesis
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-15588-50mg-safety-datasheet.pdf