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KN-92 (phosphate)

KN-92 (phosphate)

Item no.	HY-15517A-10mg
Manufacturer	MedChem Express
CASRN	1135280-28-2
Amount	10 mg
Quantity options	10mM/1mL 10 mg 2 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	99.94
Formula	C24H28ClN2O7PS
Citations	J Endocrinol. 2018 Mar;236(3):151-165. <br/>Nat Metab. 2020 Sep;2(9):918-933.<br/>Sci Rep. 2023 Dec 7;13(1):21712.<br/>Cell Calcium. 2021 Oct 5;100:102483.<br/>J Mol Cell Cardiol. 2021 Nov 10;S0022-2828(21)00210-8.<br/>[1]Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070.<br/>[2]An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.
Smiles	O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O.O=P(O)(O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1135280-28-2
Available
Product Description	KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 phosphate is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	554.98
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic)
Target	Others
Manufacturers Target	Others
Manufacturers Pathway	Others
Manufacturers Product type	Reference compound

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HY-15517A-10mg-safety-datasheet.pdf