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Monomethyl auristatin E

Monomethyl auristatin E

Item no.	HY-15162-5mg
Manufacturer	MedChem Express
CASRN	474645-27-7
Amount	5 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1 g 1mg 200mg 250 mg 25mg 500 mg 50 mg 5 mg
Category	Oncology Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules By Organ Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.98
Formula	C39H67N5O7
Citations	[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.<br/>[2]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
Smiles	CC(C)[C@H](NC)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MMAE; SGD-1010; Vedotin
Available
Product Description	Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
MolecularWeight	717.98
Clinical Information	Phase 4
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 48 mg/mL\|Ethanol : 50 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	ADC Cytotoxin; Apoptosis; Microtubule/Tubulin
Manufacturers Target	ADC Cytotoxin; Apoptosis; Microtubule/Tubulin
Isoform	Auristatin
Manufacturers Pathway	Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	ADC Related

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-15162-5mg-safety-datasheet.pdf