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Dizocilpine (maleate)

Dizocilpine (maleate)

Item no.	HY-15084-10mg
Manufacturer	MedChem Express
CASRN	77086-22-7
Amount	10 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Food Safety Allergenes Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.99
Formula	C20H19NO4
Citations	Cell Host Microbe. 2023 Nov 8;31(11):1792-1803.e7.<br/>Cell. 2023 Nov 22;186(24):5347-5362.e24.<br/>Eur J Pharmacol. 2019 Aug 15;857:172427. <br/>Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641.<br/>Front Cell Dev Biol. 2020 Feb 4;8:24. <br/>Front Cell Neurosci. 2019 Jun 25;13:276.<br/>Front Neurosci. 2019 Nov 19;13:1225.<br/>Life Sci. 2022 Feb 17;295:120419.<br/>Mol Psychiatry. 2022 Jun 17.<br/>Neuroreport. 2017 May 24;28(8):444-450. <br/>Basic and Clinical Neuroscience. 2021 Jul.<br/>Bioorg Med Chem. 2022 Feb 18;59:116675.<br/>Br J Pharmacol. 2020 Oct;177(20):4720-4733.<br/>Brain Res. 2023 May 17;1812:148409.<br/>Cell Biosci. 2023 Mar 16;13(1):57.<br/>Eur J Pharmacol. 2022 Oct 25;175343.<br/>Front Biosci (Landmark Ed). 2023 Jul 19, 28(7), 140.<br/>Int J Mol Sci. 2022 Dec 18;23(24):16150.<br/>J Cell Mol Med. 2020 Aug;24(16):9287-9299.<br/>J Med Chem. 2023 May 2.<br/>J Physiol. 2023 Jul 8.<br/>Mol Neurobiol. 2023 Dec 8.<br/>Molecules. 2023 Mar 2.<br/>Nat Neurosci. 2021 Dec 9.<br/>Neurosci Lett. 2023 Sep 4;137471.<br/>RSC Adv. 2022 Oct 3;12(43):28098-28103.<br/>[1]Wong EH, et al. The anticonvulsant MK-801 is a potent N-Me-D-Asp antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.<br/>[2]Vardhan Reddy KH, et al. Convergent Strategy to Dizocilpine MK-801 and Derivatives. J Org Chem. 2018 Apr 6;83(7):4264-4269.<br/>[3]Huettner JE, et al. Block of N-Me-D-Asp-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb;85(4):1307-11.<br/>[4]Thomas DM, et al. MK-801 and dextromethorphan block microglial activation and protect against neurotoxicity. Brain Res. 2005 Jul 19;1050(1-2):190-8.<br/>[5]Brown TE, et al. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem. 2008 Dec 2;15(12):857-65.<br/>[6]Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-Me-D-Asp receptor activation. Neuroreport. 2017 May 24;28(8):444-450.<br/>[7]Iijima Y, et al. Modification by MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist sensitization: evaluation by ambulation in mice. Nihon Shinkei Seishin Yakurigaku Zasshi. 1996 Feb;16(1):11-8.
Smiles	C[C@]12C3=CC=CC=C3C[C@@H](N2)C4=CC=CC=C14.O=C(O)/C=C\C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(+)-MK 801 Maleate
Available
Product Description	Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	337.37
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 133.33 mg/mL (ultrasonic)\|Ethanol : 25 mg/mL (ultrasonic)\|H2O : 7.69 mg/mL (ultrasonic)
Target	iGluR
Manufacturers Target	iGluR
Isoform	NMDA Receptor
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-15084-10mg-safety-datasheet.pdf