Item no. |
HY-15036A-10g |
Manufacturer |
MedChem Express
|
CASRN |
78213-16-8 |
Amount |
10 g |
Quantity options |
10 g
10mM/1mL
500 mg
5 g
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.96 |
Formula |
C18H22Cl2N2O2 |
Citations |
Pharm Res. 2022 Aug 24.<br/>Arch Microbiol. 2024 Jun 7;206(7):289.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. <br/>Toxicol Mech Methods. 2019 Nov;29(9):654-664.<br/>bioRxiv. 2024 Apr 7.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>Chem-Biol Interact. 2021, 109425.<br/>Chemosphere. 2019 Jun;225:378-387. <br/>Eur J Drug Metab Pharmacokinet. 2022 Jun 22.<br/>Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov.<br/>Int J Mol Sci. 2022, 23(20), 12066.<br/>J Hazard Mater. 2015 May 30;289:18-27.<br/>J Pharmaceut Biomed. 2021, 114105.<br/>J Phys Chem Solids. 2017 October;109:117-123.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.<br/>[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.<br/>[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. |
Smiles |
O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl.CCNCC |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
78213-16-8 |
Available |
|
Product Description |
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
369.29 |
Clinical Information |
Launched |
Manufacturers Research Area |
Inflammation/Immunology; Cancer |
Solubility |
DMSO : 150 mg/mL (ultrasonic) |
Target |
Apoptosis; COX |
Manufacturers Target |
Apoptosis; COX |
Isoform |
COX-1; COX-2 |
Manufacturers Pathway |
Apoptosis; Immunology/Inflammation |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.