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Sildenafil (citrate)

Sildenafil (citrate)

Item no.	HY-15025A-10mg
Manufacturer	MedChem Express
CASRN	171599-83-0
Amount	10mg
Quantity options	100 mg 10mM/1mL 10mg 200 mg 500 mg 50 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	99.73
Citations	Sci Rep. 2020 Oct 2;10(1):16383.<br/>ACS Omega. 2020 Nov 15;5(46):29935-29942.<br/>Biochem Biophys Res Commun. 2021 Feb 12;547:9-14.<br/>Biochim Biophys Acta Mol Basis Dis. 2024 Jan 5:167018.<br/>Bioeng Transl Med. 2023 Jul 2.<br/>Biomed Chromatogr. 2024 Jun 5:e5925.<br/>Int J Mol Sci. 2022 Jun 20;23(12):6860.<br/>Physiol Rep. 2023 Jan;11(1):e15549.<br/>[1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7.<br/>[2]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.<br/>[3]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.<br/>[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11.
Smiles	O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1.O=C(CC(C(O)=O)(O)CC(O)=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UK-92480 (citrate)
Available
Product Description	Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	666.70
Clinical Information	Launched
Manufacturers Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 2 mg/mL (ultrasonic)
Target	Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE)
Manufacturers Target	Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE)
Isoform	PDE5
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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