« Back
Home /
Prinaberel

Prinaberel

Item no.	HY-14933-50mg
Manufacturer	MedChem Express
CASRN	524684-52-4
Amount	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.05
Formula	C15H10FNO3
Citations	[1]Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040.<br/>[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.<br/>[3]Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018 May 1.
Smiles	OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ERB-041
Available
Product Description	Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	271.24
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 40 mg/mL
Target	Apoptosis; Estrogen Receptor/ERR; Wnt
Manufacturers Target	Apoptosis; Estrogen Receptor/ERR; Wnt
Isoform	ERα; ERβ
Manufacturers Pathway	Apoptosis; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-14933-50mg-safety-datasheet.pdf