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Lificiguat

Lificiguat

Item no.	HY-14927-5mg
Manufacturer	MedChem Express
CASRN	170632-47-0
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.74
Formula	C19H16N2O2
Citations	[1]Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14.<br/>[2]Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.<br/>[3]Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25.<br/>[4]Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.
Smiles	OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	YC-1
Available
Product Description	Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	304.34
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Target	Guanylate Cyclase
Manufacturers Target	Guanylate Cyclase
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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HY-14927-5mg-safety-datasheet.pdf