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Givinostat (hydrochloride monohydrate)

Givinostat (hydrochloride monohydrate)

Item no.	HY-14842B-10mM
Manufacturer	MedChem Express
CASRN	732302-99-7
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Aging & Neurological Disorders Neural Epigenetics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C24H30ClN3O5
Citations	J Mol Med (Berl). 2019 Aug;97(8):1183-1193.<br/>Acta Pharmacol Sin. 2021 Apr 13.<br/>Cell Prolif. 2021 May 24;e13072.<br/>Commun Biol. 2021 Oct 29;4(1):1235.<br/>J Orthop Transl. 29 (2021) 106-112.<br/>Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8.<br/>SSRN. 2024 Mar 13.<br/>Cell Death Dis. 2020 Sep 15;11(9):753.<br/>[1]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.<br/>[2]Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.<br/>[3]Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.
Smiles	O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ITF-2357 hydrochloride monohydrate
Available
Product Description	Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	475.97
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 2.94 mg/mL (ultrasonic; warming; heat to 60°C)
Target	HDAC
Manufacturers Target	HDAC
Isoform	HD1; HD2; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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HY-14842B-10mM-safety-datasheet.pdf