Item no. |
HY-14648-10mM |
Manufacturer |
MedChem Express
|
CASRN |
50-02-2 |
Amount |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
1 g
500 mg
5 g
|
Category |
|
Type |
Inhibitors |
Clone |
N/A |
Specific against |
other |
Purity |
99.86 |
Formula |
C22H29FO5 |
Citations |
[1]LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.<br/>[2]Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11<br/>[3]Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F76-83.<br/>[4]Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11(7):3391-3397.<br/>[5]Yoshioka Y, et al. Glabridin inhibits dexamethasone-induced muscle atrophy. Arch Biochem Biophys. 2019 Mar 30;664:157-166.<br/>[6]Troncoso R, et al. Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance. Cell Cycle. 2014;13(14):2281-95.<br/>[7]Ong SL, et al. Hemodynamics of dexamethasone-induced hypertension in the rat. Hypertens Res. 2009 Oct;32(10):889-94.<br/>[8]Nakamoto H, et al. Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Clin Exp Hypertens A. 1991;13(4):587-606.<br/>[9]Mesripour A, et al. The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair. Nutr Neurosci. 2019 Oct;22(10):744-749. <br/>[10]Bhatt S, et al. Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. Basic Clin Pharmacol Toxicol. 2016 Jul;119(1):10-8.<br/>[11]Song D, et al. Physiologically Based Pharmacokinetics of Dexamethasone in Rats. Drug Metab Dispos. 2020 Sep;48(9):811-818. |
Smiles |
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(CO)=O)O)=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Hexadecadrol; Prednisolone F |
Available |
|
Product Description |
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research[1][2][3][4]. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-anti-virus |
MolecularWeight |
392.46 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Infection; Endocrinology; Inflammation/Immunology |
Solubility |
DMSO : 116.67 mg/mL (ultrasonic)|Ethanol : 8.33 mg/mL (ultrasonic) |
Target |
ADC Cytotoxin; Antibiotic; Autophagy; Bacterial; Complement System; Glucocorticoid Receptor; Mitophagy; SARS-CoV |
Manufacturers Target |
ADC Cytotoxin; Antibiotic; Autophagy; Bacterial; Complement System; Glucocorticoid Receptor; Mitophagy; SARS-CoV |
Manufacturers Pathway |
Antibody-drug Conjugate/ADC Related; Anti-infection; Autophagy; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.