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Apilimod (mesylate)

Apilimod (mesylate)

Item no.	HY-14644A-50mg
Manufacturer	MedChem Express
CASRN	870087-36-8
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Formula	C25H34N6O8S2
Citations	bioRxiv. 2023 Aug 12.<br/>bioRxiv. 2024 Jan 23.<br/>Biomaterials. 2022 Jun;285:121509.<br/>bioRxiv. 2020 Apr 21;2020.04.21.053058. <br/>bioRxiv. 2023 Apr 28.<br/>bioRxiv. 2023 Aug 12.<br/>bioRxiv. 2023 Aug 28.<br/>bioRxiv. 2024 May 10.<br/>biorxiv. 2024 May 27.<br/>Biotechnol J. 2022 Dec 7;e2200147.<br/>Br J Cancer. 2020 Aug;123(4):542-555.<br/>Cancer Lett. 2023 Oct 6:216435.<br/>Cell Mol Life Sci. 2016 Dec;73(24):4717-4737. <br/>Commun Biol. 2022 Mar 24;5(1):262.<br/>J Biol Chem. 2022 Dec 6;102775.<br/>J Virol. 2021 Aug 18;JVI0097521.<br/>Mol Biol Cell. 2022 Jan 12;mbcE21060309.<br/>Nat Commun. 2020 Mar 27;11(1):1620.<br/>PLoS Pathog. 2023 Feb 24;19(2):e1011202.<br/>Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2307423120.<br/>Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121.<br/>Sci Adv. 2022 Jul 22;8(29):eabn1440.<br/>Sci Adv. 2023 Oct 13;9(41):eadh1134.<br/>SSRN. 2024 Jan 26.<br/>Theranostics. 2020 Mar 4;10(9):3925-3938.<br/>Viruses. 2021 Jun 28;13(7):1255.<br/>Viruses. 2023 Jun 12, 15(6), 1353.<br/>[1]Wada Y, et al. Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood. 2007 Feb 1;109(3):1156-64.<br/>[2]Billich A. Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency.IDrugs. 2007 Jan;10(1):53-9.<br/>[3]Keino H, et al. Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther. 2008;10(5):R122.
Smiles	CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.CS(=O)(O)=O.CS(=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	STA 5326 (mesylate); LAM-002A; AIT-101 (mesylate)
Similar products	870087-36-8
Available
Product Description	Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively[1]. Apilimod is a potent and highly selective PIKfyve inhibitor.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	610.70
Clinical Information	Phase 2
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 12.5 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Target	Interleukin Related; PIKfyve
Manufacturers Target	Interleukin Related; PIKfyve
Isoform	IL-12; IL-23; IL-4; IL-5; IL-8
Manufacturers Pathway	Immunology/Inflammation; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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