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Pimavanserin

Pimavanserin

Item no.	HY-14557-100mg
Manufacturer	MedChem Express
CASRN	706779-91-1
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10mg 200mg 25 mg 50 mg 5mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.86
Formula	C25H34FN3O2
Citations	ACS Chem Neurosci. 2019 Nov 20;10(11):4476-4491. <br>bioRxiv. 2020 Feb.<br>Department Neuroscience. Virginia Commonwealth University. 2016 Oct.<br>Int J Clin Exp Med. 2019;12(8):10342-10349<br>Int J Neuropsychopharmacol. 2021 Jul 6;pyab040.<br>J Med Chem. 2023 Jun 28.<br>Patent. US20200352950A1.<br>Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26438-26447.<br>Sci Rep. 2024 Jan 16;14(1):1396.<br>bioRxiv. 2023 Jul 31.<br>Food Chem Toxicol. 2023 Apr 24;113800.<br>Nat Commun. 2023 Dec 15;14(1):8221.<br>[1]Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.<br>[2]Vanover KE, et al. A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model. Pharmacol Biochem Behav. 2008 Oct;90(4):540-4.
Smiles	CC(C)COC1=CC=C(CNC(N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)=O)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ACP-103
Available
Product Description	Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	427.55
Clinical_Information	Launched
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturers Target	5-HT Receptor
Isoform	5-HT2 Receptor
Pathway	GPCR/G Protein; Neuronal Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-14557-100mg-safety-datasheet.pdf