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Fosaprepitant (dimeglumine)

Fosaprepitant (dimeglumine)

Item no.	HY-14407A-10mM
Manufacturer	MedChem Express
CASRN	265121-04-8
Amount	10 mMx1 mL
Quantity options	100 mg 10 mMx1 mL 10 mg 50 mg 5 mg
Category	Food Safety Drugs Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.0
Citations	[1]Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48(4): 394-398. New J Chem. 29th November 2021. Cancer Biol Ther. 2019;20(5):653-665.
Smiles	O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-0517, L785298
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Neurokinin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	1004.83
Product Description	Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].
Manufacturer - Research Area	Neurological Disease; Endocrinology; Cancer
Solubility	10 mM in DMSO\|H2O : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Launched

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HY-14407A-10mM-safety-datasheet.pdf