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Indomethacin

Indomethacin

Item no.	HY-14397-10mM
Manufacturer	MedChem Express
CASRN	53-86-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 1 g 500 mg 5 g
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules Stem Cell Markers
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C19H16ClNO4
Citations	[1]Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.<br/>[2]Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71.<br/>[3]Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404.<br/>[4]Helleberg L, et, al. Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58.<br/>[5]Sabiu S, et, al. Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin a nd Ficus exasperate. Toxicol Rep. 2015 Jan 8:2:261-267.<br/>[6]Danisman B, et, al, Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation. Biomedicines. 2023 Mar 9;11(3):829.
Smiles	COC1=CC=C(N(C(C2=CC=C(Cl)C=C2)=O)C(C)=C3CC(O)=O)C3=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Indometacin
Available
Product Description	Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research[1][2][3].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	357.79
Clinical Information	Launched
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 12.5 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Target	Antibiotic; Bacterial; COX; Influenza Virus
Manufacturers Target	Antibiotic; Bacterial; COX; Influenza Virus
Isoform	COX-1; COX-2
Manufacturers Pathway	Anti-infection; Immunology/Inflammation
Manufacturers Product type	Reference compound

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HY-14397-10mM-safety-datasheet.pdf