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TGR5 Receptor Agonist

TGR5 Receptor Agonist

Item no.	HY-14229-10mM
Manufacturer	MedChem Express
CASRN	1197300-24-5
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Lipoprotein Receptors & Associated Proteins Inhibitors & Compound Libraries Small Molecules Other Lipid\Cholesterol Metabolism Modulators
Type	Inhibitors
Specific against	other
Purity	99.86
Formula	C18H14Cl2N2O2
Citations	[1]Caldwell A, Grundy L, Harrington AM, Garcia-Caraballo S, Castro J, Bunnett NW, Brierley SM. TGR5 agonists induce peripheral and central hypersensitivity to bladder distension. Sci Rep. 2022 Jun 15;12(1):9920.<br>[2]Castellanos-Jankiewicz A, et al. Hypothalamic bile acid-TGR5 signaling protects from obesity. Cell Metab. 2021 Jul 6;33(7):1483-1492.e10.<br>[3]Evans KA, et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5.
Smiles	ClC1=CC=CC=C1C2=NOC(C)=C2C(N(C)C3=CC=C(Cl)C=C3)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CCDC
Available
Product Description	TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	361.22
Clinical_Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : ≥ 48 mg/mL
Manufacturers Target	Calcium Channel; G protein-coupled Bile Acid Receptor 1
Pathway	GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

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HY-14229-10mM-safety-datasheet.pdf