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Raf inhibitor 1 (dihydrochloride)

Raf inhibitor 1 (dihydrochloride)

Item no.	HY-14177A-5mg
Manufacturer	MedChem Express
CASRN	1191385-19-9
Amount	5mg
Quantity options	100 mg 10mg 1 ea 50mg 5mg
Category	Oncology Neuroscience Neural Signaling By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Inhibitors & Compound Libraries Small Molecules Astrocytoma
Type	Inhibitors
Specific against	other
Citations	[1]Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.
Smiles	CC1=CC=C2C(C=CN=C2NC3=CC=C(Cl)C=C3)=C1NC4=NC=CC=C4C5=NC=NC6=C5N=CN6.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1191385-19-9
Available
Product Description	B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.
Shipping	Room temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	551.86
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Raf
Manufacturers Target	Raf
Isoform	BRaf; c-Raf
Manufacturers Pathway	MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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