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Compound E

Compound E

Item no.	HY-14176-25mg
Manufacturer	MedChem Express
CASRN	209986-17-4
Amount	25 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.97
Formula	C27H24F2N4O3
Citations	[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.<br/>[2]Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88.
Smiles	FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	γ-Secretase-IN-1
Available
Product Description	Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	490.50
Clinical Information	Phase 4
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	γ-secretase
Manufacturers Target	γ-secretase
Manufacturers Pathway	Neuronal Signaling; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-14176-25mg-safety-datasheet.pdf