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GSK189254A

GSK189254A

Item no.	HY-14111-1mg
Manufacturer	MedChem Express
CASRN	720690-73-3
Amount	1 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Lipoprotein Receptors & Associated Proteins Lipid & Fatty Acid Transport Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer
Type	Inhibitors
Specific against	other
Purity	98.09
Formula	C21H25N3O2
Citations	[1]Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45.<br>[2]Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Br J Pharmacol. 2009 May;157(1):104-17.
Smiles	O=C(NC)C(C=N1)=CC=C1OC2=CC(CC3)=C(C=C2)CCN3C4CCC4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GSK189254 (free base)
Available
Product Description	GSK189254A (GSK189254 free base) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	351.44
Clinical_Information	Phase 2
Manufacturers Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 25 mg/mL (ultrasonic)
Manufacturers Target	Histamine Receptor
Isoform	H3 Receptor
Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-14111-1mg-safety-datasheet.pdf