SKI II

Item no.	HY-13822-10mM
Manufacturer	MedChem Express
CASRN	312636-16-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 25 mg 50 mg
Category	Oncology Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.78
Formula	C15H11ClN2OS
Citations	[1]Liu H, et al. SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/β-catenin signaling pathway. Life Sci. 2016 Apr 15;151:23-9.<br/>[2]Liu Y, et al. SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncol Lett. 2014 Jul;8(1):367-373.<br/>[3]Potì F, et al. SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. Atherosclerosis. 2015 May;240(1):212-5.<br/>[4]French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):596-603.
Smiles	OC1=CC=C(NC2=NC(C3=CC=C(Cl)C=C3)=CS2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	312636-16-1
Available
Product Description	SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC50 values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	302.78
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Target	Apoptosis; SphK; Wnt
Manufacturers Target	Apoptosis; SphK; Wnt
Manufacturers Pathway	Apoptosis; Immunology/Inflammation; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-13822-10mM-safety-datasheet.pdf