Item no. |
HY-13755A-1mg |
Manufacturer |
MedChem Express
|
CASRN |
142825-10-3 |
Amount |
1mg |
Quantity options |
10 mg
1mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.37 |
Citations |
[1]De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27;19(6):6975-86.<br/>[2]Abdull Razis AF, et al. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128(12):2775-82.<br/>[3]Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000;60(5):1426-1433.<br/>[4]Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36(1):53-64. doi: 10.3892/ijmm.2015.2199. Epub 2015 Apr 28. <br/>[5]Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50.<br/>[6]Chen X, et al. Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of PancreaticCancer via AMPK Dependent Signaling. ell Physiol Biochem. 2018;50(3):1201-1215.<br/>[7]Licznerska B, et al. R-sulforaphane modulates the expression profile of AhR, ERα, Nrf2, NQO1, and GSTP in human breast cell lines. Mol Cell Biochem. 2021;476(2):525-533. |
Smiles |
O=[S@@](CCCCN=C=S)C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
L-Sulforaphane |
Available |
|
Product Description |
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses[1][2][3][4][5][6][7]. |
StorageTemperature |
-20°C (Powder, protect from light) |
Shipping |
Blue Ice |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
177.29 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Inflammation/Immunology |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
Bcl-2 Family; Caspase; Keap1-Nrf2; NF-κB; Reactive Oxygen Species |
Manufacturers Target |
Bcl-2 Family; Caspase; Keap1-Nrf2; NF-κB; Reactive Oxygen Species |
Isoform |
Bax; Caspase 3; NF-κB |
Manufacturers Pathway |
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB |
Manufacturers Product type |
Natural Products |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.