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Folinic acid (calcium)

Folinic acid (calcium)

Item no.	HY-13664-500mg
Manufacturer	MedChem Express
CASRN	1492-18-8
Amount	500 mg
Quantity options	100 mg 10 mMx1 mL 500 mg 50 mg
Category	Food Safety Vitamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.71
Formula	C20H21CaN7O7
Citations	[1]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. [2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. EBioMedicine. 2024 Mar 13:102:105041. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Nat Commun. 2020 Apr 14;11(1):1792. Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15. bioRxiv. 2023 Feb 28. JAMA Oncol. 2022 Jan 1;8(1):e215445. Mol Oncol. 2020 Nov;14(11):2894-2919. NPJ Precis Oncol. 2023 Dec 8;7(1):128. Patent. US20230101335A1. Virology. 2023 Jun 21. J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Smiles	O=C(N[C@H](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Leucovorin (calcium), Calcium folinate
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Antifolate; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	511.50
Product Description	Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].
Manufacturer - Research Area	Cancer
Solubility	H2O : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-13664-500mg-safety-datasheet.pdf