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Folinic acid (calcium)

Folinic acid (calcium)

Item no.	HY-13664-10mM
Manufacturer	MedChem Express
CASRN	1492-18-8
Amount	10mM*1 mL
Quantity options	100 mg 10mM*1 mL 500 mg 50 mg
Category	Food Safety Vitamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.71
Citations	EBioMedicine. 2024 Mar 13:102:105041.<br>J Mol Med (Berl). 2019 Aug;97(8):1183-1193.<br>Nat Commun. 2020 Apr 14;11(1):1792.<br>Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15.<br>bioRxiv. 2023 Feb 28.<br>JAMA Oncol. 2022 Jan 1;8(1):e215445.<br>Mol Oncol. 2020 Nov;14(11):2894-2919.<br>NPJ Precis Oncol. 2023 Dec 8;7(1):128.<br>Virology. 2023 Jun 21.<br>J Mol Med (Berl). 2019 Aug;97(8):1183-1193.<br>[1]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8.<br>[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.
Smiles	O=C(N[C@H](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Leucovorin (calcium); Calcium folinate
Available
Product Description	Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	511.50
Clinical_Information	Launched
Manufacturers Research Area	Cancer
Solubility	H2O : 50 mg/mL (ultrasonic)
Manufacturers Target	Antifolate; Endogenous Metabolite
Isoform	Human Endogenous Metabolite
Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

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Amount: 10mM*1 mL

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