Comparison

Crolibulin European Partner

Item no. HY-13603-100mg
Manufacturer MedChem Express
CASRN 1000852-17-4
Amount 100 mg
Quantity options 100 mg 10mM/1mL 10 mg 1mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 98.99
Citations [1]Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6(27):24376-92.<br/>[2]Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398.<br/>[3]S. P. Anthony, et al. EPC2407, a new beta-tubulin vascular disrupting agent with potent apoptosis and cell growth inhibition. Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007) 14043-14043.
Smiles N#CC1=C(N)OC2=C(N)C(N)=CC=C2[C@H]1C3=CC(OC)=C(OC)C(Br)=C3
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias EPC2407
Available
Product Description
Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2][3].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
Cancer-programmed cell death
MolecularWeight
417.26
Clinical Information
Phase 2
Manufacturers Research Area
Cancer
Solubility
DMSO : 125 mg/mL (ultrasonic; warming)
Target
Apoptosis; Microtubule/Tubulin
Manufacturers Target
Apoptosis; Microtubule/Tubulin
Manufacturers Pathway
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
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