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Chlorambucil

Chlorambucil

Item no.	HY-13593-10mM
Manufacturer	MedChem Express
CASRN	305-03-3
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.86
Formula	C14H19Cl2NO2
Citations	[1]Guo JX, et al. Synergistic effects of chlorambucil and TRAIL on apoptosis and proliferation of Raji cells. Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4703-4710.<br/>[2]Salem FS, et al. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital. 2011 Jan-Mar;47(1):89-95.<br/>[3]Mohamed D, et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol. 2009;22(8):1435-1446.<br/>[4]Birnbaum AD, et al. Chlorambucil and malignancy. Ophthalmology. 2010;117(7):1466-1466.e1.
Smiles	O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CB-1348; WR-139013
Available
Product Description	Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	304.21
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 24 mg/mL
Target	DNA Alkylator/Crosslinker
Manufacturers Target	DNA Alkylator/Crosslinker
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-13593-10mM-safety-datasheet.pdf