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Nocodazole

Nocodazole

Item no.	HY-13520-10mg
Manufacturer	MedChem Express
CASRN	31430-18-9
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Heart & Blood Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.66
Formula	C14H11N3O3S
Citations	[1]Anutosh Ganguly, et al. The role of microtubules and their dynamics in cell migration. J Biol Chem. 2012 Dec 21;287(52):43359-69.<br>[2]Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002<br>[3]Wang YJ, et al. R-41400 potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210.<br>[4]Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6.<br>[5]Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.<br>[6]Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92.
Smiles	O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Oncodazole; R17934
Available
Product Description	Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	301.32
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 20 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Autophagy; Bcr-Abl; CRISPR/Cas9; Microtubule/Tubulin
Isoform	Abl
Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-13520-10mg-safety-datasheet.pdf