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Rupatadine (Fumarate)

Rupatadine (Fumarate)

Item no.	HY-13511A-500mg
Manufacturer	MedChem Express
CASRN	182349-12-8
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Oncology Food Safety Histamines Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Brain Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.77
Formula	C30H30ClN3O4
Citations	Pharmaceutics. 2020 Jun 8;12(6):525. Biomed Pharmacother. 2024 Jun 4:176:116826. [1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21. [2]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60. [3]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.
Smiles	CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1.O=C(O)/C=C/C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UR-12592 (Fumarate)
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Autophagy; Histamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	532.03
Product Description	Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 30 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H1 Receptor
Clinical information	Launched

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HY-13511A-500mg-safety-datasheet.pdf