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JNJ-7777120

JNJ-7777120

Item no.	HY-13508-10mg
Manufacturer	MedChem Express
CASRN	459168-41-3
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bone Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.85
Formula	C14H16ClN3O
Citations	[1]Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. <br/>[2]Ohsawa Y, et al. The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice. Allergy. 2012 Aug;67(8):1014-22.
Smiles	O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	459168-41-3
Available
Product Description	JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	277.75
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : ≥ 50 mg/mL
Target	Histamine Receptor
Manufacturers Target	Histamine Receptor
Isoform	H4 Receptor
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-13508-10mg-safety-datasheet.pdf