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LY-364947

LY-364947

Item no.	HY-13462-10mM
Manufacturer	MedChem Express
CASRN	396129-53-6
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules Neurodegeneration Markers;Research Area Oncology By Organ Pancreatic Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.14
Formula	C17H12N4
Citations	[1]Oka M, et al. Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood, 2008, 111(9), 4571-4579.<br>[2]Naka K, et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature, 2010, 463(7281), 676-680.<br>[3]Peng SB, et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry, 2005, 44(7), 2293-2304.
Smiles	C1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HTS466284
Available
Product Description	LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	272.30
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	TGF-β Receptor
Pathway	TGF-beta/Smad

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-13462-10mM-safety-datasheet.pdf