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Tofogliflozin (hydrate)

Tofogliflozin (hydrate)

Item no.	HY-13413-50mg
Manufacturer	MedChem Express
CASRN	1201913-82-7
Amount	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.48
Formula	C22H28O7
Citations	Biochem Pharmacol. 2018 Jun;152:45-59.<br>University of Paris. 2022 Sep 19.<br>Biochem Pharmacol. 2016 Feb 1;101:27-39. <br>J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Mar 15;1141:122020.<br>[1]Ishibashi Y, et al. Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation. Horm Metab Res. 2016 Mar;48(3):191-5.<br>[2]Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.
Smiles	O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]21OCC3=C2C=C(CC4=CC=C(CC)C=C4)C=C3.O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CSG-452 hydrate
Available
Product Description	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2[1]. Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	404.45
Clinical_Information	Launched
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 0.33 mg/mL (ultrasonic)
Manufacturers Target	Reactive Oxygen Species; SGLT
Isoform	SGLT2
Pathway	Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

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HY-13413-50mg-safety-datasheet.pdf