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Tubastatin A

Tubastatin A

Item no.	HY-13271A-200mg
Manufacturer	MedChem Express
CASRN	1252003-15-8
Amount	200 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Epigenetics Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.37
Formula	C20H21N3O2
Citations	Acta Pharm Sin B. 20 May 2022.<br/>Aging. 2021 Mar 19;13(7):9820-9837.<br/>Am J Pathol. 2020 Dec;190(12):2376-2386.<br/>Antioxidants (Basel). 2022 Apr 7;11(4):732.<br/>Antioxidants. 2020 Jul 9;9(7):599.<br/>Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118676.<br/>bioRxiv. 2021 Feb 25.<br/>BMC Biol. 2018 Oct 18;16(1):116.<br/>J Dermatol Sci. 2022 May 17;S0923-1811(22)00125-6.<br/>J Med Chem. 2023 Nov 16.<br/>J Mol Neurosci. 2024 Mar 13.<br/>J Nutr. 2020 Jul 1;150(7):1790-1798.<br/>Medical Science, University of Toronto. 2017 Nov.<br/>Mol Cancer Res. 2014 May;12(5):681-93.<br/>Mol Cancer Res. 2022 Mar 4;molcanres.0923.2021.<br/>Neurotherapeutics. 2023 Jun 2.<br/>NPJ Precis Oncol. 2024 Mar 7;8(1):66.<br/>Patent. US20180263995A1.<br/>Atherosclerosis. 2021 Jan;317:1-9.<br/>Cell Death Dis. 2022 Oct 21;13(10):888.<br/>Front Pharmacol. 2018 Feb 1;9:34.<br/>Hum Mol Genet. 2022 Jan 12;ddac008.<br/>Neurotherapeutics. 2023 Jun 2.<br/>PLoS Pathog. 2021 Sep 20;17(9):e1009940.<br/>[1]Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846<br/>[2]de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78.<br/>[3]Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563<br/>[4]Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9.<br/>[5]Kozyreva VK, et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014 May;12(5):681-93.<br/>[6]Brijmohan, Angela, et al. Role of HDAC6 in Transcription Factor EB Mediated Clearance of Misfolded Proteins in Chronic Kidney Disease. University of Toronto.Nov-2017.<br/>[7]Lechner S, Malgapo MIP, Grätz C, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target [published online ahead of print, 2022 Apr 28]. Nat Chem Biol. 2022;10.1038/s41589-022-01015-5. <br/>[8]Géraldy M, Morgen M, Sehr P, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019;62(9):4426-4443.<br/>[9]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.
Smiles	O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1252003-15-8
Available
Product Description	Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	335.40
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 12.5 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Target	Apoptosis; Autophagy; Beta-lactamase; HDAC
Manufacturers Target	Apoptosis; Autophagy; Beta-lactamase; HDAC
Isoform	HDAC1; HDAC6; HDAC8
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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HY-13271A-200mg-safety-datasheet.pdf