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A-674563

A-674563

Item no.	HY-13254-10mg
Manufacturer	MedChem Express
CASRN	552325-73-2
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Bladder Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.87
Formula	C22H22N4O
Citations	Cell Signal. 2023 Jun 9;109:110753.<br/>J Proteome Res. 2018 Oct 5;17(10):3360-3369.<br/>Oncotarget. 2016 May 17;7(20):29131-42. <br/>Aging. 2020 Nov 17;12(22):23114-23128.<br/>[1]Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther, 2005, 4(6), 977-986.<br/>[2]Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res, 2008, 68(8), 2895-2903.<br/>[3]Zou Y, et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent. Biochem Biophys Res Commun. 2016 Aug 12;477(1):1-8.<br/>[4]Xu L, et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8.<br/>[5]Wang A, et al. Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML. Oncotarget. 2016 May 17;7(20):29131-42.
Smiles	N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(C=C3)NN=C4C)=CN=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	552325-73-2
Available
Product Description	A-674563 is an orally active and selective Akt1 inhibitor with a Ki of 11 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	358.44
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 83.33 mg/mL (ultrasonic)
Target	Akt
Manufacturers Target	Akt
Isoform	Akt1
Manufacturers Pathway	PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-13254-10mg-safety-datasheet.pdf