RepSox

Item no.	HY-13012-10mM
Manufacturer	MedChem Express
CASRN	446859-33-2
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer S100 Calcium Binding Protein B Markers
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.92
Formula	C17H13N5
Citations	[1]Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. [2]Wan-Zhi Tu, et al. RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes. Acta Pharmacol Sin. 2019 Dec;40(12):1523-1531.
Smiles	CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	E-616452, SJN 2511
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Organoid; TGF-β Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	287.32
Product Description	RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Stem Cell/Wnt; TGF-beta/Smad
Isoform	ALK5
Clinical information	No Development Reported

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HY-13012-10mM-safety-datasheet.pdf