NTP42

Item no.	HY-129851-100mg
Manufacturer	MedChem Express
CASRN	2055599-51-2
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.02
Formula	C25H23F2N3O5S
Citations	[1]B. Therese KINSELLA, et al. Thromboxane receptor antagonists. WO2016203314A1.<br/>[2]Eamon Mulvaney, et al. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
Smiles	O=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2055599-51-2
Available
Product Description	NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619[1]. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH)[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	515.53
Clinical Information	Phase 1
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 31.25 mg/mL (ultrasonic)
Target	Prostaglandin Receptor
Manufacturers Target	Prostaglandin Receptor
Isoform	TXA2/TP
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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HY-129851-100mg-safety-datasheet.pdf