Item no. |
HY-12820-10mM |
Manufacturer |
MedChem Express
|
CASRN |
1616113-45-1 |
Amount |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
1 mg
25 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.70 |
Formula |
C35H39NO11 |
Citations |
[1]W Reinisch, et al. P568 An open-label, multicenter, phase ib, pharmacokinetic (pk) and safety study of a fimh blocker, Sibofimloc (TAK-018/EB8018), in patients with Crohn’s disease (CD), Journal of Crohn's and Colitis, Volume 14, Issue Supplement_1, January 2020: S479–S480.<br>[2]Ramtohul, Yeeman K, et al. Preparation of mannose derivatives via coupling and click cycloaddition reactions for treating bacterial infections. From PCT Int. Appl. (2014), WO 2014100158 A1 20140626. |
Smiles |
CC(N(CC1)CCC21C3=CC(C#C[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC=C3C5=CC=C(C#C[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)C=C52)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Antibiotic-202 |
Available |
|
Product Description |
Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD)[1][2]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
649.68 |
Clinical_Information |
Phase 2 |
Manufacturers Research Area |
Infection |
Solubility |
DMSO : 125 mg/mL (ultrasonic) |
Manufacturers Target |
Antibiotic; Bacterial |
Pathway |
Anti-infection |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.