BPTES

Item no.	HY-12683-5mg
Manufacturer	MedChem Express
CASRN	314045-39-1
Amount	5 mg
Quantity options	10mM/1mL 10 mg 50mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Lymphatic System Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.98
Formula	C24H24N6O2S3
Citations	[1]Elgogary A, et al. Combination therapy with BPTES nanoparticles and targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36.<br/>[2]Meghan J. Seltzer, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010 Nov 15; 70(22): 8981-8987.<br/>[3]Lee JS, et al. Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC. Biochem Biophys Res Commun. 2016 Aug 26;477(3):374-82<br/>[4]Lee JS, et al. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell Death Dis. 2016 Dec 8;7(12):e2511.
Smiles	O=C(NC1=NN=C(CCSCCC2=NN=C(NC(CC3=CC=CC=C3)=O)S2)S1)CC4=CC=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	314045-39-1
Available
Product Description	BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	524.68
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : < 0.1 mg/mL
Target	Glutaminase
Manufacturers Target	Glutaminase
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-12683-5mg-safety-datasheet.pdf