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AS2863619 (free base)

AS2863619 (free base)

Item no.	HY-126675-100mg
Manufacturer	MedChem Express
CASRN	2241300-50-3
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.87
Formula	C16H12N8O
Citations	[1]Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.
Smiles	NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2241300-50-3
Available
Product Description	AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	332.32
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	CDK; STAT
Manufacturers Target	CDK; STAT
Isoform	CDK19; CDK8; GSK-3α; GSK-3β; STAT5
Manufacturers Pathway	Cell Cycle/DNA Damage; JAK/STAT Signaling; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-126675-100mg-safety-datasheet.pdf