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Rhosin (hydrochloride)

Rhosin (hydrochloride)

Item no.	HY-12646-10mg
Manufacturer	MedChem Express
CASRN	1281870-42-5
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 5 mg
Category	Cell Biology Cytoskeleton Inhibitors & Compound Libraries Small Molecules small GTPases Rho Subfamily
Type	Inhibitors
Specific against	other
Purity	99.93
Formula	C20H19ClN6O
Citations	Acta Pharmacol Sin. 2024 Mar 15.<br/>Biochem Pharmacol. 2023 Sep 23;115816.<br/>bioRxiv. 2023 Oct 16.<br/>Cancer Biol Ther. 2018;19(12):1193-1203. <br/>Circulation. 2021 May 4;143(18):1775-1792.<br/>Ecotoxicol Environ Saf. 2022 May 1;236:113454.<br/>Ecotoxicol Environ Saf. 2023 Apr 24;257:114940.<br/>Endocrinology. 2021 Apr 14;bqab077.<br/>FASEB J. 2020 Jan;34(1):1481-1496.<br/>J Mol Med (Berl). 2023 Oct 7.<br/>Kardiol Pol. 2021 Jun 27.<br/>Microcirculation. 2021 Jan 23;e12680.<br/>Nat Commun. 2023 Mar 14;14(1):1402.<br/>Oncol Rep. 2021 Jan;45(1):83-94.<br/>Theranostics. 2022 May 9;12(8):3847-3861.<br/>Antioxidants (Basel). 2022, 11(7), 1264.<br/>Biochem Biophys Res Commun. 2019 Oct 29;519(1):134-140.<br/>Cancer Res. 2022 Feb 15;82(4):681-694.<br/>Cell Death Dis. 2023 Apr 20;14(4):280.<br/>Cell Mol Bioeng. 06 October 2022.<br/>Chem Biol Interact. 17 August 2021, 109625.<br/>Exp Cell Res. 2024 Mar 1;436(1):113956.<br/>J Breast Cancer. 2019 Apr 22;22(2):185-195. <br/>SSRN. 2024 Feb 13.<br/>[1]Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710.<br/>[2]Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.<br/>[3]Francis TC, et al. The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability. Biol Psychiatry. 2019;85(12):1001-1010.
Smiles	O=C(N/N=C/C1=CC=C2N=CC=NC2=C1)[C@H](N)CC3=CNC4=C3C=CC=C4.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1281870-42-5
Available
Product Description	Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	394.86
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 16.67 mg/mL (ultrasonic)
Target	Apoptosis; Ras
Manufacturers Target	Apoptosis; Ras
Manufacturers Pathway	Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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HY-12646-10mg-safety-datasheet.pdf