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LY2510924

LY2510924

Item no.	HY-12488-5mg
Manufacturer	MedChem Express
CASRN	1088715-84-7
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	99.73
Formula	C62H88N14O10
Citations	[1]Peng SB, et al. Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models. Mol Cancer Ther. 2015 Feb;14(2):480-90. [2]Cho BS, et al. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. Blood. 2015 Jul 9;126(2):222-32.
Smiles	O=C(NCC(N[C@H](CCC(N[C@H]1CC2=CC=CC=C2)=O)C(N[C@H](C(N)=O)CCCCNC(C)C)=O)=O)[C@@H](NC([C@@](NC([C@@H](NC([C@H](NC1=O)CC3=CC=C(O)C=C3)=O)CCCCNC(C)C)=O)([H])CCCNC(N)=N)=O)CC4=CC(C=CC=C5)=C5C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1088715-84-7
Available
Product Description	LY2510924 is a potent and selective CXCR4 antagonist that blocks SDF-1 binding to CXCR4 with an IC50 of 0.079 nM.
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1189.45
Clinical Information	Phase 2
Manufacturers Research Area	Cancer; Endocrinology
Solubility	DMSO : ≥ 125 mg/mL\|H2O : ≥ 100 mg/mL
Target	CXCR
Manufacturers Target	CXCR
Isoform	CXCR4
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12488-5mg-safety-datasheet.pdf