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VLX1570

VLX1570

Item no.	HY-12471-10mM
Manufacturer	MedChem Express
CASRN	1431280-51-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	98.03
Formula	C23H17F2N3O6
Citations	[1]Wang X, et al. Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15. Chem Biol Drug Des. 2015 Nov;86(5):1036-48.<br/>[2]Wang X, et al. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep. 2016 Jun 6;6:26979.<br/>[3]Paulus A, et al. Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells. Blood Cancer J. 2016 Nov 4;6(11):e492.
Smiles	O=C1/C(CN(C(C=C)=O)CC/C1=C\C2=CC=C(F)C([N+]([O-])=O)=C2)=C/C3=CC=C(F)C([N+]([O-])=O)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1431280-51-1
Available
Product Description	VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC50 of approximate 10 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	469.39
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 32 mg/mL
Target	Deubiquitinase
Manufacturers Target	Deubiquitinase
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-12471-10mM-safety-datasheet.pdf