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A-1210477

A-1210477

Item no.	HY-12468-50mg
Manufacturer	MedChem Express
CASRN	1668553-26-1
Amount	50 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.40
Formula	C46H55N7O7S
Citations	[1]Leverson JD, et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis. 2015 Jan 15;6:e1590. [2]Qing Wang, et al. A-1210477, a selective MCL-1 inhibitor, overcomes ABT-737 resistance in AML. Oncol Lett. 2019 Nov;18(5):5481-5489.
Smiles	O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1668553-26-1
Available
Product Description	A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM[1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	850.04
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 10 mg/mL (ultrasonic)
Target	Apoptosis; Bcl-2 Family
Manufacturers Target	Apoptosis; Bcl-2 Family
Isoform	Bcl-2; Bcl-W; Bfl-1; Mcl-1
Manufacturers Pathway	Apoptosis
Manufacturers Product type	Reference compound

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HY-12468-50mg-safety-datasheet.pdf