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OTS964 (hydrochloride)

OTS964 (hydrochloride)

Item no.	HY-12467-25mg
Manufacturer	MedChem Express
CASRN	1338545-07-5
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 2mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.74
Formula	C23H25ClN2O2S
Citations	Cell Death Dis. 2019 Aug 5;10(8):583. Cell. 2021 Jun 10;184(12):3143-3162.e32. Nature. 2022 Sep;609(7928):829-834. SSRN. 2022 Nov 21. Adv Sci (Weinh). 2024 Feb 2:e2308496. iScience. 2023 Jun 16. J Eur Acad Dermatol Venereol. 2023 Dec 22. [1]Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition ofcytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145. [2]Lin A, et al. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. Sci Transl Med. 2019 Sep 11;11(509). [3]Lu H, et al. TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ. Cell Death Dis. 2019 Aug 5;10(8):583.
Smiles	OC1=CC(C)=C2C(C3=C(SC=C3)C(N2)=O)=C1C4=CC=C([C@@H](C)CN(C)C)C=C4.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1338545-07-5
Available
Product Description	OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM[1]. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	428.97
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 83.33 mg/mL\|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Apoptosis; CDK; TOPK
Manufacturers Target	Apoptosis; CDK; TOPK
Isoform	CDK11
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-12467-25mg-safety-datasheet.pdf