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6H05 (TFA)

6H05 (TFA)

Item no.	HY-12408A-10mM
Manufacturer	MedChem Express
CASRN	2061344-88-3
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.02
Formula	C22H31ClF3N3O4S3
Citations	[1]Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.
Smiles	O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2061344-88-3
Available
Product Description	6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	590.14
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 51 mg/mL\|H2O : ≥ 100 mg/mL
Target	Ras
Manufacturers Target	Ras
Manufacturers Pathway	GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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HY-12408A-10mM-safety-datasheet.pdf