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(-)-Indolactam V

(-)-Indolactam V

Item no.	HY-12307-10mM
Manufacturer	MedChem Express
CASRN	90365-57-4
Amount	10mM/1mL
Quantity options	10mM/1mL 1 mg 5 mg
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules Progenitor Markers
Type	Inhibitors
Specific against	other
Purity	99.30
Formula	C17H23N3O2
Citations	[1]Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61(8):1415-7.<br/>[2]Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7.<br/>[3]Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5(4):258-65.
Smiles	CC(C)[C@@H](C1=O)N(C)C2=C3C(NC=C3C[C@H](N1)CO)=CC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Indolactam V
Available
Product Description	(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	301.38
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	PKC
Manufacturers Target	PKC
Isoform	PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCη; PKCθ
Manufacturers Pathway	Epigenetics; TGF-beta/Smad
Manufacturers Product type	Reference compound

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HY-12307-10mM-safety-datasheet.pdf