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Ocifisertib (fumarate)

Ocifisertib (fumarate)

Item no.	HY-12300B-5mg
Manufacturer	MedChem Express
CASRN	1616420-30-4
Amount	5 mg
Quantity options	100 mg 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.44
Citations	Int J Mol Med. 2021 Jan;47(1):151-160. Ir J Med Sci. 2022 May 4. J Cancer Res Clin Oncol. 2020 Nov;146(11):2871-2883. Nat Nanotechnol. 2021 Jul;16(7):830-839. [1]Sampson PB, et al. The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent. J Med Chem. 2015 Jan 8;58(1):147-69. [2]Mason JM, et al. Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell. 2014 Aug 11;26(2):163-76.
Smiles	OC(/C=C/C(O)=O)=O.O=C1[C@@]2(C3=CC(OC)=CC=C3N1)[C@H](C4=CC=C(C(/C=C/C5=CC=C(C=C5)CN6C[C@H](O[C@H](C6)C)C)=NN7)C7=C4)C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CFI-400945 (fumarate)
Available
Product Description	CFI-400945 fumarate is a potent, selective and orally bioavailable PLK4 inhibitor with a Ki and an IC50 of 0.26 nM and 2.8 nM, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	650.72
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 0.5 mg/mL (ultrasonic; warming)
Target	Polo-like Kinase (PLK)
Manufacturers Target	Polo-like Kinase (PLK)
Isoform	PLK4
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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