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Setanaxib

Setanaxib

Item no.	HY-12298-10mg
Manufacturer	MedChem Express
CASRN	1218942-37-0
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.45
Formula	C21H19ClN4O2
Citations	[1]Green DE, et al. The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Am J Respir Cell Mol Biol. 2012 Nov;47(5):718-26.<br>[2]Aoyama T, et al. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec;56(6):2316-27.
Smiles	O=C1N(C2=CC=CC=C2Cl)NC(C1=C(C3=CC=CC(N(C)C)=C3)N4C)=CC4=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GKT137831; GKT831
Available
Product Description	Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	394.85
Clinical_Information	Phase 2
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Ferroptosis; NADPH Oxidase
Isoform	NOX1; NOX4
Pathway	Apoptosis; Metabolic Enzyme/Protease

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12298-10mg-safety-datasheet.pdf